Does Oral Sermorelin Work? What the Evidence Shows

What is sermorelin?

Sermorelin is a 29-amino-acid peptide that copies the active part of growth hormone-releasing hormone (GHRH).

GHRH is a signal the body uses to tell the pituitary gland when to release growth hormone. In published studies of the injectable product Geref, sermorelin given by vein or under the skin stimulated the pituitary gland [1]. These findings do not apply to compounded tablets.

Was sermorelin ever FDA approved?

Yes, as an injection called Geref. It was later discontinued, and FDA found it was not withdrawn for safety or effectiveness reasons.

Geref sermorelin injection was approved for use in children with growth hormone deficiency and as a diagnostic test. In 2013, FDA published a determination that the Geref products were not withdrawn from sale for reasons of safety or effectiveness [2]. Sermorelin prescribed today through telehealth is compounded, which means a pharmacy prepares it for one patient. Compounded medications are not FDA approved.

Does oral sermorelin work?

There is no published clinical evidence that answers this question.

The human research on sermorelin used intravenous or subcutaneous injections [1]. We searched PubMed and found no published clinical trials of sermorelin taken as a tablet, a dissolving tablet or by mouth. Peptides face a harsh environment in the digestive tract, and researchers describe the oral route as unfavorable for peptide drugs [3]. That does not prove an oral form cannot work. It means the question has not been studied in published trials.

Why do people ask about tablets?

Preference and routine, not evidence of better results.

Some people prefer to avoid needles, so they ask whether a tablet works. A tablet is a format choice. Stackhaus Health does not offer sermorelin tablets. Your provider can explain what is and is not known about each form.

What are the side effects?

In injection studies, the most common side effects were facial flushing and pain at the injection site [1].

Headache and nausea have also been reported with sermorelin. Because compounded sermorelin is not FDA approved, complete information about how often side effects occur with each form is limited.

Important safety information. Tell your provider if you are pregnant or breastfeeding, have a pituitary or thyroid condition, or have a history of cancer. Your provider reviews your health history and medications before prescribing.

How does Stackhaus Health approach sermorelin?

Stackhaus Health offers compounded sermorelin as an injection only. A licensed provider reviews your intake and decides whether it is appropriate. Your provider sets any dose.

Compounded sermorelin is not FDA approved. If prescribed, a state-licensed pharmacy prepares and ships it. See compounded sermorelin injection, all longevity options, and our editorial policy.